Monday, April 22, 2013

Two Linked Drugs Are Better Than One

The MIT Technology Review has a short article describing a new strategy for double dosing multiple drugs; linking them together:
Catabasis has found a way around the challenge of identifying a single active molecule that can hit multiple pathways effectively: using a chemical linker to bring together two active molecules. The synergistic effect of the linked molecules may arise from the fact that the two compounds both “get to the right place at the right time.”
The company, Catabasis Pharmaceuticals, is developing a technology that can combine two compounds together using a linker that supposedly puts the drugs into an inactive form in the bloodstream, but which is cut within cells when the whole package is absorbed.